In vitro skin penetration of dazmegrel delivered with a bioelastic matrix
Barbara W Kemppainen1, Dan W Urry, Chi-Xiang Luan
1Department of Anatomy, Physiology, & Pharmacology, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA. kemppbw@auburn.edu
International Journal of Pharmaceutics
|May 8, 2004
Abstract:
The penetration of dazmegrel, a selective thromboxane synthetase inhibitor, through excised human and greyhound skin was measured. A bioelastic matrix was used for topical delivery. Results demonstrated that dazmegrel readily penetrated the skin. Penetration through greyhound skin was significantly greater than penetration through human skin. Penetration through greyhound skin was not significantly different between 4, 24, and 48 h of exposure for the low and intermediate doses studied.


