Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stimulating human accommodation without changes in focus.

Monika Weiss1, Anne Seidemann, Frank Schaeffel

  • 1Section of Neurobiology of the Eye, University Eye Hospital, Calwerstr. 7/1, 72076 Tuebingen, Germany.

Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)
|May 8, 2004
PubMed
Summary

Stimulating specific retinal pathways (ON/OFF) created a depth illusion but did not consistently drive accommodation responses in humans. This suggests limited direct input from these systems into proximal accommodation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to comments by Kulkarni et al. on our article "Interactions of choroid and sclera in the myopia model of the chicken", http://doi:10.1016/j.exer.2026.110904.

Experimental eye research·2026
Same author

Interactions of choroid and sclera in the myopia model of the chicken.

Experimental eye research·2026
Same author

Short-term axial eye length changes after imposed defocus in emmetropes, myopes and hyperopes.

Vision research·2026
Same author

Pilot study: non-invasive binocular fundal pulsation measurements using infrared photorefraction.

Biomedical optics express·2025
Same author

IMI: The Role of Light in Refractive Development and Myopia: Evidence from Animal and Human Studies.

Investigative ophthalmology & visual science·2025
Same author

Retinal proteomic analysis reveals ON/OFF visual stimulation-specific changes in a Guinea pig myopia model.

Experimental eye research·2025

Area of Science:

  • Vision Science
  • Neuroscience
  • Ophthalmology

Background:

  • Animal studies suggest specific retinal pathways (ON and OFF systems) influence refractive development.
  • ON system stimulation suppresses myopia, while OFF system stimulation suppresses hyperopia in chickens.

Purpose of the Study:

  • To investigate if ON-OFF retinal system stimulation can elicit directional accommodation responses in humans.
  • To explore the potential role of accommodation in emmetropization, mirroring image processing algorithms.

Main Methods:

  • Accommodation responses were measured using an infrared photorefractor (PowerRefractor) in 13 human subjects.
  • A computer-generated stimulus with ON-OFF system stimulation, looming, and low-pass filtering was presented.
  • An artificial pupil minimized confounding accommodation cues, operating under open-loop conditions.

Related Experiment Videos

Main Results:

  • ON/OFF stimulation induced a strong depth illusion but minimal accommodation responses.
  • Looming stimuli elicited accommodation consistent with perceived proximity in most subjects.
  • Accommodation responses were significantly reduced or absent in closed-loop conditions after removing the artificial pupil.

Conclusions:

  • Preferential ON/OFF retinal stimulation has a limited direct impact on proximal accommodation in humans.
  • The study highlights the complexity of accommodation control, with potential inputs requiring further investigation.
  • Findings suggest ON/OFF pathways may not be primary drivers of human accommodation in the same way as observed in chickens.