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Whole Blood Assay with Dual Co-Stimulation for Antigen-Specific Analysis of Host Immunity to Fungal and Viral Pathogens
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Role of T cell costimulation in anti-viral immunity

Edward M Bertram1, Wojciech Dawicki, Tania H Watts

  • 1Australian Phenomics Facility and Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia 2601.

Seminars in Immunology
|May 8, 2004
PubMed

Members of both the CD28 and TNFR families can have costimulatory roles in T cell activation. Gene targeted mice as well as in vivo blocking experiments have established distinct roles for CD28/B7; ICOS/ICOSL; CD27/CD70; 4-1BB/4-1BBL and OX40/OX40L during viral infection. Many issues remain to be addressed, including the timing and location of the interactions, the possibility of partial redundancy between related family members and the molecular basis for the specific phenotypes observed in the different gene targeted mice.

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