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Updated: Aug 24, 2026

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
Published on: August 5, 2021
Electrochemically assisted co-precipitation of protein with calcium phosphate coatings on titanium alloy
Xiaoliang Cheng1, Mark Filiaggi, Sharon G Roscoe
1Department of Chemistry, Acadia University, 6 University Ave, Wolfville, Nova Scotia, Canada B4P 2R6.
Abstract:
A bovine serum albumin protein-containing calcium phosphate coating (BSA/brushite) was prepared by electrochemically assisted co-precipitation onto a hydroxyapatite (HA) coated Ti-6Al-4V surface. Electrochemically assisted co-precipitation of BSA/brushite coatings onto HA resulted in a 70-fold increase in BSA inclusion compared to simple adsorption, and was subsequently released by a slower mechanism (15% loss over 70 h). Thus, this electrochemically assisted co-precipitation technique provides an efficient method of protein incorporation at physiological temperature, with a potential for sustained release of therapeutic agents as may be required for metallic implant fixation.
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