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Chlorhexidine release from an experimental glass ionomer cement
G Palmer1, F H Jones, R W Billington
1Department of Biomaterials, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256, Gray's Inn Road, London WC1X 8LD, UK. gpalmer@eastman.ucl.ac.uk
Biomaterials
|May 8, 2004
Summary
This study explored using glass ionomer cements (GIC) to release chlorhexidine acetate (CHA). While some CHA released, most remained in the GIC, affecting cement properties like strength and setting time.
Area of Science:
- Materials Science
- Biomaterials Science
- Dental Materials
Background:
- Glass ionomer cements (GIC) are known for slow fluoride ion release.
- Investigating GIC as matrices for other active agents is a promising area.
Purpose of the Study:
- To evaluate an experimental GIC as a carrier for chlorhexidine acetate (CHA) release.
- To quantify CHA release kinetics and assess the impact on GIC properties.
Main Methods:
- Incorporation of CHA (0.5-13.0% by weight) into an experimental GIC.
- High-performance liquid chromatography (HPLC) to measure CHA release in water.
- X-ray photoelectron spectroscopy (XPS) for surface chemistry analysis.
- Measurement of compressive strength, working time, and setting time.
Main Results:
- Measurable CHA release occurred within 22 h1/2, but less than 10% of incorporated CHA was released.
- Higher CHA concentration in GIC powder led to increased release.
- XPS confirmed significant CHA retention within the GIC matrix.
- Compressive strength decreased with increasing CHA content, while working and setting times increased.
Conclusions:
- The experimental GIC demonstrated limited release of CHA, retaining the majority within the cement matrix.
- CHA incorporation negatively impacts GIC mechanical properties and setting characteristics.
- Further research is needed to optimize GIC formulations for effective and sustained release of agents like CHA.