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Related Experiment Videos

Cisplatin-induced emesis in Suncus murinus.

M Mutoh1, H Imanishi, Y Torii

  • 1Basic Research Laboratories, Toray Industries, Inc., Kanagawa, Japan.

Japanese Journal of Pharmacology
|March 1, 1992
PubMed
Summary

Cisplatin induces vomiting by activating vagal nerves, likely through its metabolite cis-diamminediamineplatinum (DAP). This study in suncus confirms the critical role of vagal innervation in chemotherapy-induced emesis.

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Area of Science:

  • Pharmacology
  • Neuroscience
  • Gastroenterology

Background:

  • Chemotherapy-induced nausea and vomiting (CINV) are significant side effects of cancer treatment.
  • Cisplatin is a widely used chemotherapeutic agent known to cause severe emesis.

Purpose of the Study:

  • To investigate the emetic responses to cisplatin in suncus.
  • To elucidate the role of vagal innervation in cisplatin-induced emesis.

Main Methods:

  • Administered cisplatin via intraperitoneal and intravenous routes to suncus.
  • Assessed dose-dependent emetic responses, including ED50, latency, and frequency.
  • Investigated the effect of cis-diamminediamineplatinum (DAP), a cisplatin metabolite.
  • Performed vagotomy to assess the involvement of vagal nerves.

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Main Results:

  • Cisplatin administration resulted in dose-dependent emesis, with no significant differences between administration routes.
  • Cis-diamminediamineplatinum (DAP) also induced emesis, but with a shorter latency.
  • Vagotomy completely abolished cisplatin-induced emesis.

Conclusions:

  • Cisplatin is metabolized to DAP, which likely stimulates vagal afferents to induce emesis.
  • Vagal innervation plays a crucial role in mediating cisplatin-induced emesis.