Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Protein structure prediction and analysis as a tool for functional genomics.

Edward N Baker1, Vickery L Arcus, J Shaun Lott

  • 1Centre of Molecular Biodiscovery and School of Biological Sciences, University of Auckland, Auckland, New Zealand. ted.baker@auckland.ac.nz

Applied Bioinformatics
|May 8, 2004
PubMed
Summary

Understanding uncharacterized gene products requires determining their 3D protein structures. Protein structure prediction methods and structural genomics projects are key to uncovering biochemical functions and advancing biological research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ancestral neuronal receptors are bacterial accessory toxins.

Nature communications·2026
Same author

Arrhenius Activation Energy Is Not a Useful Predictor of Soil Organic Matter Transformation and Its Consequences for Global Warming.

Global change biology·2026
Same author

Complete structures of the YenTc holotoxin prepore and pore reveal the evolutionary basis for chitinase incorporation into ABC toxins.

Nature communications·2025
Same author

Protease mimicry: Dissecting the ester bond crosslinking mechanics in bacterial adhesin proteins.

Protein science : a publication of the Protein Society·2025
Same author

Feedback regulation of iron-sulfur cluster biogenesis.

bioRxiv : the preprint server for biology·2025
Same author

A minimal biophysical model for the temperature dependence of CO2 fixation rates based on macromolecular rate theory.

PloS one·2025

Area of Science:

  • Structural biology
  • Bioinformatics
  • Genomics

Background:

  • Bioinformatic analysis of whole genomes reveals numerous uncharacterized gene products.
  • Determining the three-dimensional (3D) structure of proteins is crucial for understanding their biochemical and cellular functions.
  • Protein structure dictates biological activity, making structure determination a powerful approach to functional annotation.

Discussion:

  • Current protein structure prediction methods include ab initio prediction, fold recognition, and comparative modeling based on homology.
  • These computational approaches offer valuable insights but have inherent limitations.
  • The growth of experimentally determined protein structure databases is essential for future advancements.

Key Insights:

  • Protein structure prediction from sequence data is a vital tool for functional genomics.

Related Experiment Videos

  • Structural genomics projects, like the one focused on Mycobacterium tuberculosis, are accelerating the discovery of protein functions.
  • Integrating predicted and experimental structures enhances our understanding of biological systems.

    • Outlook:

    • Continued expansion of structural databases through structural genomics will be a major driver in the field.
    • Advancements in prediction algorithms and experimental structure determination hold promise for annotating more uncharacterized proteins.
    • Understanding protein structures is critical for tackling diseases like tuberculosis.