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MHCPred: bringing a quantitative dimension to the online prediction of MHC binding

Pingping Guan1, Irini A Doytchinova, Christianna Zygouri

  • 1Edward Jenner Institute for Vaccine Research, Berkshire, UK.

Applied Bioinformatics
|May 8, 2004
PubMed

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Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
Binding sites are often located in large pockets, and if their location on a protein’s surface is unknown, it can be predicted using various approaches. The energetic method computationally analyses the...