Related Experiment Videos
Improved left ventricular contractility with cool temperature hemodialysis.
F L Levy1, P A Grayburn, C J Foulks
1Department of Internal Medicine, Veterans Affairs Medical Center, Dallas, Texas.
Kidney International
|April 1, 1992
Summary
Cool temperature dialysis (CTD) improves heart function during hemodialysis. This method enhances left ventricular contractility, potentially explaining its effectiveness in preventing hypotension during treatment.
Area of Science:
- Nephrology
- Cardiology
- Physiology
Background:
- Cool temperature dialysis (CTD) reduces intradialytic hemodialysis hypotension.
- The mechanism behind CTD's hemodynamic protection remains unclear.
Purpose of the Study:
- To investigate the effect of CTD on left ventricular contractility.
- To explore the potential mechanism of hemodynamic protection offered by CTD.
Main Methods:
- Two-dimensional echocardiography was used to assess left ventricular contractility in six hemodialysis patients.
- Left ventricular function was evaluated by plotting the rate-corrected velocity of circumferential fiber shortening (Vcfc) against end-systolic wall stress (sigma es) before and after dialysis at 37°C (RTD) and 35°C (CTD).
Main Results:
- Post-dialysis Vcfc was significantly higher after CTD compared to RTD (1.13 ± 0.29 vs. 0.98 ± 0.30 circ/sec, P = 0.0004).
- The Vcfc–sigma es relation shifted upward post-CTD, indicating increased left ventricular contractility.
- No significant changes in mean arterial pressure or heart rate were observed post-dialysis for either RTD or CTD.
Conclusions:
- Cool temperature dialysis enhances left ventricular contractility in hemodialysis patients.
- Increased contractility may be the mechanism improving hemodynamic tolerance during CTD.