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Cognitive inflexibility after prefrontal serotonin depletion

H F Clarke1, J W Dalley, H S Crofts

  • 1Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK.

Science (New York, N.Y.)
|May 8, 2004
PubMed
Summary

Selective serotonin depletion in the prefrontal cortex (PFC) impairs behavioral flexibility, causing perseverative responding. This finding is crucial for understanding neuropsychiatric disorders like OCD and schizophrenia.

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