Modeling diabetic sensory neuropathy in rats
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Updated: Aug 24, 2026
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An Ultrasonic Tool for Nerve Conduction Block in Diabetic Rat Models
Published on: October 20, 2017
1Department of Pathology, University of California San Diego, La Jolla, USA.
Methods in Molecular Medicine
|May 8, 2004
Abstract:
The procedures to induce insulin-deficient diabetes in rats using streptozotocin are described along with a number of insulin treatment regimes that can be used to maintain these animals at different degrees of glycemia for periods of weeks to months. Streptozotocin-diabetic rats develop tactile allodynia, hyperalgesia following paw formalin injection and abnormal responses to thermal stimulation and the detailed methods used to evaluate these behavioral indices of abnormal sensory function are provided.
