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Updated: Aug 24, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Two furopyridine complexes of nickel(II) isothiocyanate
Jozef Miklovic1, Alzbeta Krutosíková, Peter Baran
1Department of Chemistry, Faculty of Natural Sciences, University of St Cyril and Methodius, SK 917 01 Trnava, Slovakia.
Abstract:
Pyridine fused with a furan ring (fupy), and its dimethyl derivative, have been used for the first time as ligands to synthesize potentially new Werner clathrates. The extended aromatic system of pyridine-like ligands influences considerably the molecular structure of prepared nickel complexes. The molecular structure of tetrakis(furo[3,2-c]pyridine)bis(isothiocyanato)nickel(II) tetrahydrofuran (THF) solvate, [Ni(NCS)(2)(C(7)H(5)NO)(4)].C(4)H(8)O or [Ni(NCS)(2)(fupy)(4)].THF, (I), reveals a 'four-blade propeller' arrangement of ligands, with the angles between the fupy planes and the basal octahedron plane spanning the range 38.7-55.3 degrees. These angles are much larger (69.9-78.8 degrees ) in the centrosymmetric complex tetrakis(2,3-dimethylfuro[3,2-c]pyridine)bis(isothiocyanato)nickel(II) 6.6-hydrate, [Ni(NCS)(2)(C(9)H(9)NO)(4)].6.6H(2)O or [Ni(NCS)(2)(Me(2)fupy)(4)].6.6H(2)O, (II), in which crystallographically imposed inversion symmetry is present.
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