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Bupropion sustained release for panic disorder.

Naomi M Simon1, Naresh Emmanuel, James Ballenger

  • 1Department of Psychiatry, Harvard University, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. nsimon@partners.org

Psychopharmacology Bulletin
|May 8, 2004
PubMed
Summary
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Bupropion SR may effectively treat panic disorder, significantly reducing symptoms like panic attacks and anxiety. Further controlled studies are needed to confirm these promising findings for panic disorder treatment.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Limited prospective data exists on bupropion for panic disorder.
  • Clinical observations and prior studies suggest bupropion may not be effective for panic disorder.

Purpose of the Study:

  • To investigate the efficacy of bupropion SR in treating panic disorder with or without agoraphobia.

Main Methods:

  • An 8-week, two-center, open-label, flexible-dose trial of bupropion SR was conducted.
  • Twenty outpatients meeting criteria for panic disorder were enrolled.
  • Outcome measures included CGI Severity score, PDSS, panic attack frequency, and anticipatory anxiety.

Main Results:

  • Bupropion SR showed statistically significant reductions in CGI Severity scores for both intent-to-treat and completer samples.

Related Experiment Videos

  • Significant improvements were observed in panic symptom measures, including the PDSS, panic attack frequency, and anticipatory anxiety.

    • Conclusions:

    • Findings suggest bupropion SR may be an effective treatment for panic disorder.
    • Further controlled trials are warranted to validate these results.