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Related Experiment Videos

Transdermal delivery controlled by a chitosan membrane.

Wah Wah Thein-Han1, Willem F Stevens

  • 1Bioprocess Technology, Asian Institute of Technology, Bangkok, Thailand.

Drug Development and Industrial Pharmacy
|May 11, 2004
PubMed
Summary

This study developed a transdermal drug delivery system using chitosan membranes for controlled release of lidocaine hydrochloride. Higher chitosan deacetylation and thickness slowed drug release, showing potential for sustained anesthetic effects.

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Area of Science:

  • Materials Science
  • Pharmacology
  • Biomedical Engineering

Background:

  • Transdermal drug delivery systems (TDDS) offer advantages for sustained drug release.
  • Chitosan, a biocompatible polymer, is explored for its potential in TDDS due to its tunable properties.
  • Controlling drug release kinetics is crucial for optimizing therapeutic efficacy and minimizing side effects.

Purpose of the Study:

  • To analyze the in vitro and in vivo drug release of lidocaine hydrochloride from a transdermal system.
  • To investigate the influence of chitosan membrane properties (degree of deacetylation and thickness) on drug release kinetics.
  • To evaluate the anesthetic effect of the developed transdermal patch in human volunteers.

Main Methods:

  • In vitro drug release studies using Franz diffusion cells with varying chitosan membranes.

Related Experiment Videos

  • Development of a transdermal chitosan patch incorporating a chitosan hydrogel drug reservoir.
  • In vivo assessment of anesthetic effect on human volunteers' forearms.

    • Main Results:

    • Drug release rate decreased with increased chitosan degree of deacetylation (% DD) and membrane thickness.
    • A transdermal patch with a 95% DD chitosan membrane exhibited the most prolonged in vitro drug release.
    • Non-Fickian transport mechanism was identified for lidocaine hydrochloride.
    • In vivo studies showed delayed anesthetic onset with increasing % DD of the chitosan membrane, correlating with in vitro release.

    Conclusions:

    • A combination of chitosan membrane and chitosan hydrogel forms an effective transparent system for controlled drug delivery.
    • In vitro release kinetics of lidocaine from the chitosan system predict its in vivo anesthetic effect.
    • The direct correlation between in vitro drug permeability and in vivo physiological effect is a significant finding.