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Updated: Aug 24, 2026

Isolating Free Carbenes, their Mixed Dimers and Organic Radicals
Published on: April 19, 2019
Preparation of Re(I)- and (99m)Tc(I)-metallocarboranes in water under weakly basic reaction conditions
Oyebola O Sogbein1, Patricia Merdy, Pierre Morel
1Department of Chemistry and the Medical Physics & Applied Radiation Sciences Unit, McMaster University, 1280 Main Street West, Hamilton, Ontario, Canada, L8S 4M1.
Abstract:
A new method for the preparation of Re- and (99m)Tc-metallocarboranes in water under mild reaction conditions was developed. Three nido-carborane ligands were reacted with [Re(CO)(3)Br(3)](2)(-) in the presence of aqueous potassium fluoride to give the corresponding eta(5)-Re(CO)(3)-carborane complexes. The use of KF as a base afforded the desired Re-metallocarboranes in good yields while avoiding the formation of Re clusters, which are byproducts commonly observed when reactions are carried out in the presence of strong aqueous bases. The reaction was also performed at the tracer level producing the first (99m)Tc-carborane complex, which was isolated in 80% radiochemical yield following a simple Sep-Pak purification process. The resulting organometallic complex was stable to cysteine and histidine challenges for more than 24 h.
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