Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A gene for alcohol toxicity, not drinking behavior.

R M Goodman

    Medical Hypotheses
    |July 1, 1992
    PubMed
    Summary

    Genetic variations in human dopamine receptor genes are linked to ethanol toxicity, not directly to alcoholism or drinking behaviors. This finding clarifies previously contradictory research on gene associations with alcohol use disorders.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effect of Organic Amendments on Soilborne and Foliar Diseases in Field-Grown Snap Bean and Cucumber.

    Plant disease·2019
    Same author

    In situ detection of early replication phases of a gemini virus in legume protoplasts.

    Plant cell reports·2013
    Same author

    How to institutionalize health promotion programs.

    American journal of health promotion : AJHP·2011
    Same author

    The life and death of a health promotion program: an institutionalization case study.

    International quarterly of community health education·2010
    Same author

    Regression Analyses for Evaluating the Influence of Bacillus cereus on Alfalfa Yield Under Variable Disease Intensity.

    Phytopathology·2008
    Same author

    Up-regulation of OsBIHD1, a rice gene encoding BELL homeodomain transcriptional factor, in disease resistance responses.

    Plant biology (Stuttgart, Germany)·2005

    Area of Science:

    • Neuroscience
    • Genetics
    • Pharmacology

    Background:

    • The association between specific human dopamine receptor gene alleles and alcoholism has yielded conflicting results in previous studies.
    • Understanding the genetic underpinnings of alcohol use disorders is crucial for developing targeted interventions.

    Purpose of the Study:

    • To resolve contradictory findings regarding the association of a human dopamine receptor gene allele with alcoholism.
    • To elucidate the specific mechanism by which this gene allele influences alcohol-related outcomes.

    Main Methods:

    • Analysis of genetic data related to dopamine receptor genes.
    • Assessment of the gene's role in ethanol toxicity pathways.
    • Correlation analysis between gene allele, ethanol toxicity, and drinking behavior metrics.

    Main Results:

    • The studied dopamine receptor gene allele is significantly associated with individual differences in ethanol toxicity.
    • No direct association was found between this specific allele and self-reported drinking behavior or diagnostic criteria for alcoholism.
    • The gene's influence appears to be mediated through its role in cellular response to ethanol, rather than behavioral control of consumption.

    Conclusions:

    • The apparent link between the dopamine receptor gene allele and alcoholism is an indirect effect, primarily related to ethanol's toxic impact.
    • This research clarifies the gene's function, highlighting its role in toxicity rather than the propensity for drinking behavior.
    • Future research should consider ethanol toxicity pathways when investigating genetic predispositions to alcohol-related conditions.

    Related Experiment Videos