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Updated: Aug 24, 2026

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
Published on: May 2, 2025
Effects of copper-aspirin complex on platelet-neutrophil interactions
Zhi-qiang Shen1, Peng Chen, Ling Li
1Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Kunming 650031, China. szq21cn@hotmail.com
Aim:
To investigate the effects of copper-aspirin complex on rat thrombosis and the interaction between platelets and neutrophils.
Methods:
The model of electrically stimulated carotid artery thrombosis in Sprague Dawley rats was used; the effects of copper-aspirin complex on rat platelet-neutrophil adhesion and platelet aggregation stimulated by activated neutrophils were observed by rosette assay and Born's method, respectively.
Results:
Intragastric copper-aspirin complex (5, 7, and 10 mg/kg) dose-dependently prolonged the occlusion time; it significantly decreased the rosette number formed between thrombin-activated platelets and neutrophils; the 50 % of inhibitory concentration (IC50) was (54.6+/-4.3) micromol/L. Copper-aspirin complex markedly inhibited rat platelet aggregation induced by either cell free supernatant of activated neutrophils or by activated neutrophil suspension. The values of IC50 were (224.5+/-16.2) micromol/L and (820.5+/-21.4) micromol/L, whereas aspirin had no influence.
Conclusion:
Copper-aspirin complex inhibited platelet-neutrophil interactions through a different property from aspirin and resulted in a more potent antithrombotic activity.
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