Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcific aortic stenosis and autonomic dysfunction.

C Cronin1

  • 1Department of Medicine, Cork Regional Hospital, Wilton, Ireland.

Medical Hypotheses
|July 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High Rates of Diabetic Ketoacidosis in Patients with New and Known Type 1 Diabetes over a Six-Year Period

Irish medical journal·2019
Same author

Development of an abbreviated version of the delirium motor subtyping scale (DMSS-4).

International psychogeriatrics·2014
Same author

Charles Sugrue, M.D., of Cork (1775-1816) and the first description of a classical medical condition: phaeochromocytoma.

Irish journal of medical science·2008
Same author

MR small bowel enterography: optimization of imaging timing.

Clinical radiology·2007
Same author

A comparison of whole-body MRI and CT for the staging of lymphoma.

AJR. American journal of roentgenology·2005
Same author

Effective delivery of neonatal stabilization education using videoconferencing in Manitoba.

Journal of telemedicine and telecare·2003
Same journal

Calcitonin Gene-Related Peptide-Induced Central Sensitization: A Hypothesis for Long COVID Symptoms.

Medical hypotheses·2026
Same journal

Subclinical mastitis during lactation: a modifiable risk factor for breast cancer?

Medical hypotheses·2025
Same journal

The Role of Hemispheric Sensory Shifts: Impacts on Stretch Reflex and Motor Plasticity Post-Stroke.

Medical hypotheses·2025
Same journal

Neuron-Targeted Exosome Therapy: A Novel Approach for Treating Cardiogenic Dementia via RyR2 Inhibition.

Medical hypotheses·2025
Same journal

How the Somatosensory System Adapts to the Motor Change in Stroke: A Hemispheric Shift?

Medical hypotheses·2024
Same journal

Unstable Plaque is a Treatable Cause of Cognitive Decline.

Medical hypotheses·2024
See all related articles

Calcific aortic stenosis, a growing concern in aging populations, may stem from autonomic dysfunction. This dysfunction could impair the aortic valve, making it vulnerable to calcification from other stresses.

Area of Science:

  • Cardiovascular Medicine
  • Geriatrics
  • Neuroscience

Background:

  • Calcific aortic stenosis (CAS) is a prevalent valvular disease in aging populations.
  • The exact etiology of CAS remains largely unknown, necessitating further research into underlying mechanisms.
  • Aging of the aortic valve shares similarities with changes observed in autonomic denervation.

Purpose of the Study:

  • To propose a novel hypothesis for the pathogenesis of calcific aortic stenosis.
  • To investigate the potential role of autonomic dysfunction in the development of CAS.
  • To explore the link between autonomic denervation and age-related changes in the aortic valve.

Main Methods:

  • Comparative analysis of calcific aortic stenosis and medial arterial calcification.

Related Experiment Videos

  • Examination of similarities between autonomic denervation and natural aging of the aortic valve.
  • Review of existing literature on autonomic nervous system influence on cardiovascular tissues.

    • Main Results:

    • Aortic valvular calcification shares pathological similarities with medial arterial calcification, where autonomic dysfunction is implicated.
    • Changes observed in the aging aortic valve resemble those seen after autonomic denervation.
    • Autonomic denervation may lead to withdrawal of neurotrophic influences, creating vulnerability to calcification.

    Conclusions:

    • Autonomic dysfunction is hypothesized as the underlying abnormality in the calcification of aging aortic valves.
    • This dysfunction may predispose the aortic valve to calcification when exposed to stresses like hemodynamic trauma.
    • Understanding the role of the autonomic nervous system could offer new therapeutic targets for CAS.