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Updated: Aug 24, 2026
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Published on: October 2, 2014
[Expression and significance of heat shock protein 70, 90 in endometrial carcinomas]
Xiao-xia Bai1, Ya-qiong Chen, Xiao-yan Xin
1Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Aim:
To explore the expression and significance of heat shock protein (HSP)70, 90 in endometrial carcinomas.
Methods:
Expresssions of HSP70 and HSP90 in 30 normal endometrium, 30 endometrial hyperplasia and 53 endometrial carcinomas were detected by Envision immunohistochemical staining and imaging pattern analyser.
Results:
Gray Scale value(GS) of HSP70 in endometrial carcinoma being (209.06+/-5.36) GS was obviously higher than that in normal endometrium (145.21+/-4.09)GS, P<0.01 and endometrial hyperplasia(148.59+/-4.23)GS, P<0.01. GS of HSP90 in endometrial carcinoma being (166.98+/-5.71)GS was markedly lower than that in normal endometrium (208.57+/-3.14)GS,P<0.05 and endometrial hyperplasia (249.73+/-4.94)GS, P<0.01. Expression of HSP70 increased with increased pathological grading of tumor P<0.01, whereas HSP90 expression decreased with increased pathological grading P<0.01. Expression of HSP70 in nonendometrioid carcinoma (229.90+/-3.77)GS was higher than in endometrioid carcinoma (198.37+/-3.15)GS,P<0.01 and the expression pattern of HSP90(140.21+/-3.22)was contrary to that of HSP70 (176.59+/-2.79)GS,P<0.01. There was no correlations among expression of HSP70, 90 in endometrial carcinoma and depth invaded into muscular layer, clinical stage and lymph node metastasis.
Conclusion:
Both HSP70 and HSP90 may have relation to the genesis and prognosis of endometrial carcinoma.
