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[Effect of overall alkali of Tongbiling on CD69 expression activated mouse T lymphocytes]
Ji-fan Chen1, Guang-xing Chen, Xiao-juan Li
1The First Attached Hospital, Guangzhou TCM University, Guangzhou 510405, China. guangxing_chen@hotmail.com
Aim:
To investigate the effect of overall alkali of Tongbiling(TBL) on CD69 expression on activated mouse T lymphocytes and its possible mechanism.
Methods:
Phorbol 12,13-dibutyrate(PDB) or concanavalin (ConA) were added successively into mouse lymphocytic culture with various concentration of overall alkali TBL. After 24 hours, CD69 expression rate on mouse T lymphocytes activated with PDB or ConA was analyzed by flow cytometry.
Results:
Overall alkali TBL could significantly down-regulate CD69 expression in a dose-dependent manner.
Conclusion:
Overall alkali TBL can significantly inhibit CD69 expression on activated mouse T lymphocytes. This study provided an experimental basis for application of overall alkali TBL to treatment of rheumatoid arthritis.
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