Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Thyroid Gland01:23

The Thyroid Gland

6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

5.1K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
5.1K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

7.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.3K
Co-activators and Co-repressors02:04

Co-activators and Co-repressors

8.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.4K
What are Proteins?01:55

What are Proteins?

237.9K
Overview
237.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized controlled trial comparing a prepackaged low-residue diet with a restricted diet for colonoscopy preparation: the impact on the results of colonoscopy in adenoma detection.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Irelandยท2015
Same author

A novel measurement method for the morphology of the mandibular ramus using homologous modelling.

Dento maxillo facial radiologyยท2015
Same author

Endoscopic submucosal dissection with a ligation device for the treatment of rectal carcinoid tumor.

Endoscopyยท2012
Same author

A new formulation for orally disintegrating tablets using a suspension spray-coating method.

International journal of pharmaceuticsยท2009
Same author

Successful management of critical limb ischemia with intravenous sodium thiosulfate in a chronic hemodialysis patient.

Clinical nephrologyยท2006
Same author

Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.

Oncogeneยท2005

Related Experiment Video

Updated: Jan 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K

Nodular thyroid hyperplasia in a cynomolgus monkey.

M Kouchi1, K Okimoto

  • 1Safety Research Laboratories, Dainippon Pharmaceutical Co., Ltd., 33-94 Enoki-cho, Suita-shi, Osaka 564-0053, Japan. mami-kouchi@dainippon-pharm.co.jp.

Veterinary Pathology
|May 11, 2004
PubMed
Summary
This summary is machine-generated.

Nodular thyroid hyperplasia, a rare condition in nonhuman primates, was observed in a clinically normal cynomolgus monkey. Necropsy revealed multiple thyroid nodules with distinct follicular and cellular changes.

More Related Videos

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR
10:23

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR

Published on: February 12, 2018

12.0K
Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
08:07

Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain

Published on: July 27, 2009

13.1K

Related Experiment Videos

Last Updated: Jan 24, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.5K
Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR
10:23

Absolute Quantification of Plasma MicroRNA Levels in Cynomolgus Monkeys, Using Quantitative Real-time Reverse Transcription PCR

Published on: February 12, 2018

12.0K
Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
08:07

Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain

Published on: July 27, 2009

13.1K

Area of Science:

  • Veterinary Pathology
  • Comparative Pathology
  • Endocrinology

Background:

  • Nodular thyroid hyperplasia is an uncommon condition in nonhuman primates.
  • Thyroid gland morphology and function are crucial for overall health.

Observation:

  • A 4-year-old male cynomolgus monkey (Macaca fascicularis) presented with clinically normal status.
  • Necropsy revealed multiple, variably sized nodules in both thyroid lobes.

Findings:

  • Nodules exhibited variable follicular lumen diameters, from absent to cyst-like, with occasional papillary epithelial infoldings.
  • Immunohistochemistry confirmed thyroglobulin presence in follicular cells and colloid.
  • Ultrastructural analysis showed numerous microvilli, lysosomal bodies, and dilated rough endoplasmic reticulum in follicular cells.

Implications:

  • These findings represent a rare case of nodular thyroid hyperplasia in a cynomolgus monkey.
  • The morphologic characteristics are consistent with hyperplasia, offering insights into primate thyroid pathology.