Investigation of intermolecular interaction in molecular complex of tryptamine and benzoic acid by solid-state 2D NMR
Akira Terakita1, Hirokazu Matsunaga, Takahiro Ueda
1Analytical Development Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan. Terakita_Akira@takeda.co.jp
Abstract:
Solid-state NMR spectra and powder X-ray diffraction of the two-component molecular complex composed of tryptamine and benzoic acid were observed to investigate the intermolecular interaction in the molecular complex. 1D (13)C CP/MAS NMR spectrum and powder X-ray diffraction pattern of the complex was clearly different from the convolution of each spectrum of the single component. 2D (1)H-(13)C heteronuclear-correlation (HETCOR) NMR technique indicated that the intermolecular interaction between the primary amine of tryptamine and the carboxyl group of benzoic acid must be related to the complex formation.
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