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Related Experiment Videos

Early prenatal diagnosis by celocentesis.

G Makrydimas1, I Georgiou, I Bouba

  • 1Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece. grmak@otenet.gr

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|May 11, 2004
PubMed
Summary

Celocentesis, an early prenatal diagnostic technique, successfully obtained extra-amniotic fluid for genetic testing and paternity analysis. This method shows promise as an alternative to existing prenatal screening procedures.

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Area of Science:

  • Perinatology
  • Prenatal Diagnostics
  • Fetal Medicine

Background:

  • Celocentesis involves ultrasound-guided aspiration of extra-amniotic fluid between 7-8 weeks of gestation.
  • This procedure is explored for its clinical application in early prenatal diagnosis.

Purpose of the Study:

  • To evaluate the clinical utility of celocentesis for early prenatal diagnosis.
  • To assess the feasibility of using celocentesis for genetic testing and paternity analysis.

Main Methods:

  • Celocentesis was successfully performed in nine pregnancies, yielding 1-2 mL of fluid per aspiration.
  • Indications included prenatal diagnosis for beta-thalassemia, sickle cell disease, Marfan syndrome, and paternity testing.
  • Molecular biological techniques were employed for analyzing celomic fluid, with successful application in all cases.

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Main Results:

  • Pregnancy termination occurred in two cases based on maternal request following diagnosis of sickle cell anemia and confirmed non-paternity.
  • Results from celocentesis were confirmed post-termination using placental samples.
  • Six of seven pregnancies with desired outcomes showed concordant results when compared with later amniocentesis at 16 weeks.

Conclusions:

  • Celocentesis demonstrates potential as a viable alternative to current prenatal diagnostic methods.
  • The procedure was associated with uneventful pregnancies and healthy infant deliveries.