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Related Experiment Videos

Aryloxy phosphoramidate triesters as pro-tides.

Dominique Cahard1, Christopher McGuigan, Jan Balzarini

  • 1UMR 6014 CNRS, Université de Rouen, Mont Saint Aignan cedex, France.

Mini Reviews in Medicinal Chemistry
|May 12, 2004
PubMed
Summary

Aryloxy phosphoramidate triesters effectively deliver charged antiviral nucleoside monophosphates into cells. This review details their discovery, mechanism, structure-activity relationships, and application in antiviral therapies.

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Area of Science:

  • Medicinal Chemistry
  • Drug Delivery
  • Virology

Background:

  • Charged nucleoside monophosphates face challenges in cellular uptake.
  • Developing effective delivery systems is crucial for antiviral therapies.

Purpose of the Study:

  • To review the development of aryloxy phosphoramidate triesters as a pro-tide strategy.
  • To explore their application in intracellular delivery of antiviral agents.

Main Methods:

  • Review of literature on aryl phosphoramidate discovery.
  • Analysis of mechanism of action and structure-activity relationships.
  • Compilation of applications in antiviral nucleoside delivery.

Main Results:

  • Aryloxy phosphoramidate triesters demonstrate efficacy as pro-tides.

Related Experiment Videos

  • These compounds facilitate intracellular delivery of charged antiviral nucleoside monophosphates.
  • Structure-activity relationships provide insights for optimization.

    • Conclusions:

    • Aryloxy phosphoramidate triesters represent a promising strategy for enhancing antiviral drug delivery.
    • This approach broadens the utility of nucleoside monophosphate-based antivirals.