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B-cell antigen receptor signaling requirements for targeting antigen to the MHC class II presentation pathway

Marcus R Clark1, Donald Massenburg, Karyn Siemasko

  • 1Department of Medicine, Section of Rheumatology, University of Chicago, Chicago IL 60637, USA. mclark@medicine.bsd.uchicago.edu

Current Opinion in Immunology
|May 12, 2004
PubMed

The ability of B lymphocytes to capture, process and present antigens to T cells is requisite for normal humoral immune responses and contributes to the pathogenesis of both B- and T-cell-mediated autoimmune diseases. B lymphocytes preferentially capture polyvalent antigens, which are capable of eliciting a coordinated series of cellular responses that ensure that even low-affinity antigens are productively captured. Polyvalency not only accelerates transit through the endocytic pathway but also induces a reorganization of the antigen-processing compartment, activates degradative pathways and determines how antigenic peptides are presented to T cells. Similar changes are observed in maturing dendritic cells, indicating that some cellular responses to foreign antigens are conserved.

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