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Updated: Aug 24, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
The evolution of aldosterone antagonists
Susan M Garthwaite1, Ellen G McMahon
1Pfizer Incorporated, Global Project Management, Skokie, IL, USA.
Abstract:
Since the isolation and purification of aldosterone from adrenal extracts 50 years ago (Experientia 9 (1953) 33), scientists have learned a great deal about how and where aldosterone acts, the factors that control its release, what is its role in the pathophysiology of cardiovascular disease, how to make and study aldosterone antagonists, and for what medical purposes these agents are useful. In this paper, we will discuss the evolution of aldosterone antagonists from the relatively nonselective spironolactone (Aldactone), to the highly selective eplerenone (Inspra). Eplerenone represents a molecule with improved steroid receptor selectivity and pharmacokinetic properties in man compared to spironolactone. Recent clinical results have demonstrated that these improvements translate into tolerability and efficacy in patients with cardiovascular disease.
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