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Evaluation of ventricular diastolic function in normal children using equilibrium radionuclide angiography
1Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Nuclear Medicine Communications
|August 1, 1992
Summary
This study establishes normal diastolic function ranges in children using radionuclide angiography. These findings aid in assessing pediatric heart disease by providing reference values for peak filling rate and time to peak filling rate.
Area of Science:
- Pediatric Cardiology
- Nuclear Cardiology
- Cardiovascular Physiology
Background:
- Assessing diastolic function in children is crucial for diagnosing heart disease.
- Existing normal ranges for pediatric diastolic parameters are limited.
- Equilibrium radionuclide angiography (ERNA) is a valuable tool for cardiac function assessment.
Purpose of the Study:
- To establish normal ranges for diastolic parameters in children.
- To evaluate the utility of ERNA for determining these normal ranges.
- To provide reference values for peak filling rate (PFR) and time to peak filling rate (TPFR).
Main Methods:
- Twenty children (aged 3.3-17.5 years) underwent ERNA.
- Ventricular time-activity curves and their derivatives were analyzed.
- Ejection fraction (EF), peak ejection rate (PER), time to peak ejection rate (TPER), PFR, and TPFR were calculated.
Main Results:
- Normal ranges were established: EF (60±8%), PER (3.73±0.70 EDV/s), TPER (109±25 ms), PFR (3.84±0.51 EDVs/s), TPFR (136±21 ms).
- Significant correlations were found between PER and EF (P<0.001), and PFR and EF (P<0.05).
- Age and heart rate did not influence these variables.
Conclusions:
- Normal ranges for pediatric diastolic parameters (PFR, TPFR) were successfully determined using ERNA.
- These established ranges are essential for evaluating systolic and diastolic function in pediatric patients.
- The findings support the use of ERNA for comprehensive cardiac function assessment in children.