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Parental karyotype and subsequent live births in recurrent miscarriage
Howard Carp1, Baruch Feldman, Gabriel Oelsner
1Sheba Medical Center, Tel Hashomer, Israel. carp@netvision.net.il
Objective:
To compare the subsequent live birth rate in recurrently miscarrying women with and without parental balanced chromosomal aberrations.
Design:
Retrospective comparative cohort study.
Setting:
Tertiary referral unit in a university hospital.
Patient(S):
Nine hundred sixteen patients with 3-16 miscarriages before 20 weeks: 99 patients with and 817 patients without chromosomal aberrations.
Intervention(S):
None.
Main Outcome Measure(S):
Outcome of the subsequent pregnancy in terms of live births or repeat miscarriage.
Result(S):
Of the 916 patients, 661 subsequently conceived, 73 (73.7%) with parental chromosomal aberrations and 588 (71.9%) without aberrations. In patients with and without chromosomal aberrations, 33 of 73 pregnancies (45.2%) and 325 of 588 pregnancies (55.3%), respectively, resulted in live births. The difference is not statistically significant. There was a similar prevalence of aberrations in primary, secondary, and tertiary aborters. The prevalence of aberrations was not related to the number of previous miscarriages. Translocations, inversions, and mosaicism were followed by a similar live birth rate.
Conclusion(S):
Patients with parental chromosomal rearrangements do not have a significantly lower live birth rate than patients without aberrations. Parental karyotyping might not be a good predictor of the outcome of subsequent pregnancies.