Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

One molecule per particle method for functionalising nanoparticles.

Robert Wilson1, Yang Chen, Jenny Aveyard

  • 1Department of Chemistry, Liverpool University, Liverpool, UK. R.Wilson@liv.ac.uk

Chemical Communications (Cambridge, England)
|May 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Maximizing treatment response in patients with neuropathic-subtype postural orthostatic tachycardia syndrome.

Frontiers in neurology·2026
Same author

The Reward Positivity Tracks Positive Reward Prediction Errors From Feedback to Cues During Reinforcement Learning.

Psychophysiology·2026
Same author

Gaboxadol increases resting theta and alpha power without affecting evoked responses in fragile X syndrome in a home-based setting.

Journal of neurodevelopmental disorders·2026
Same author

Nitric oxide‑releasing porous titanium foams fabricated by scalable sintering-dissolution process for antibiofilm activity and cytocompatibility.

Scientific reports·2026
Same author

A methodological framework for validating a multi-domain physiological sensor for divers using a scalable data fusion platform.

Frontiers in physiology·2026
Same author

Correction: Establishing standardized transthoracic echocardiography reference ranges for mouse models: insights into the impact of anesthesia, sex, and age.

Frontiers in cardiovascular medicine·2026
Same journal

A one-step immunoassay of Tau protein based on flow cytometric counting of target-induced nanoaggregates.

Chemical communications (Cambridge, England)·2026
Same journal

Decarboxylative alkylation of unactivated olefins <i>via</i> photoinduced Fe-LMCT: access to alkylated dihydropyrazoles/tetrahydropyridazines.

Chemical communications (Cambridge, England)·2026
Same journal

MOF-ionic liquid engineered polymer electrolyte for advanced solid-state sodium metal batteries.

Chemical communications (Cambridge, England)·2026
Same journal

Chemically-fueled transient peptide hydrogel enabling programmable time-gated functions.

Chemical communications (Cambridge, England)·2026
Same journal

The first structurally characterized coordination compounds with homocysteine.

Chemical communications (Cambridge, England)·2026
Same journal

Bimetallic Bi-In interfaces on micropyramidal silicon for efficient solar-driven CO<sub>2</sub>-to-formate conversion.

Chemical communications (Cambridge, England)·2026
See all related articles

This study demonstrates controlled self-assembly of biotinylated dextran onto gold nanoparticles. The process ensures one dextran molecule per nanoparticle, crucial for precise bioconjugation applications.

Area of Science:

  • Nanotechnology
  • Bioconjugation Chemistry
  • Materials Science

Background:

  • Gold nanoparticles (AuNPs) are versatile nanomaterials with applications in diagnostics and therapeutics.
  • Controlled surface functionalization of nanoparticles is essential for their targeted delivery and efficacy.
  • Dextran, a polysaccharide, can be modified for bioconjugation, but achieving precise conjugation density remains a challenge.

Purpose of the Study:

  • To develop a self-assembly method for conjugating biotinylated dextran to 15 nm gold nanoparticles.
  • To achieve a controlled conjugation of one biotinylated dextran molecule per gold nanoparticle.
  • To investigate the influence of dextran molecular weight and nanoparticle size on the self-assembly process.

Main Methods:

  • Synthesis of 15 nm gold nanoparticles.

Related Experiment Videos

  • Preparation of biotinylated dextran with varying molecular weights.
  • Controlled self-assembly of biotinylated dextran onto gold nanoparticles.
  • Characterization of nanoparticle-dextran conjugates using techniques such as UV-Vis spectroscopy and dynamic light scattering.

    • Main Results:

    • Successful conjugation of biotinylated dextran to 15 nm gold nanoparticles was achieved.
    • A mean of one biotinylated dextran molecule per particle was consistently obtained.
    • The self-assembly process was found to be dependent on the interplay between dextran molecular weight and gold nanoparticle size.

    Conclusions:

    • A robust and controllable self-assembly method for creating monodisperse gold nanoparticle-dextran conjugates was established.
    • This method allows for precise control over the conjugation density, yielding one dextran molecule per nanoparticle.
    • The findings provide a foundation for developing highly specific nanoparticle-based systems for biomedical applications.