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Updated: Aug 24, 2026

Determination of the Procoagulant Activity of Extracellular Vesicle (EV) Using EV-Activated Clotting Time (EV-ACT)
Published on: August 4, 2023
[Blood coagulation disorders in children]
1Kinderklinik und Poliklinik im Dr. von Haunerschen Kinderspital, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Lindwurmstr. 4, 80337 München.
Insights
Pediatric hemorrhagic or thrombotic events stem from inborn or acquired causes, often appearing in infancy. Understanding unique pediatric features is crucial for diagnosis and effective therapy.
Area of Science:
- Pediatric Hematology
- Hemostasis and Thrombosis
Context:
- Hemorrhagic and thrombotic events occur in children, mirroring adult presentations.
- Underlying causes can be congenital (inborn) or acquired.
- Inherited disorders typically manifest in early infancy.
Purpose:
- To highlight the importance of specific pediatric features in interpreting clinical and laboratory findings.
- To establish the foundational knowledge required for selecting appropriate therapeutic strategies in pediatric patients.
Summary:
- Hemorrhagic and thrombotic events in children share similarities with adults but require specialized consideration.
- The etiology of these events in pediatric populations includes both inherited and acquired conditions.
- Early recognition of inherited disorders presenting in infancy is critical for timely intervention.
Impact:
- Facilitates accurate diagnosis and interpretation of bleeding or clotting disorders in children.
- Guides the selection of optimal and tailored treatment plans for pediatric patients.
- Improves clinical management and outcomes for children experiencing hemostatic and thrombotic complications.
Abstract:
As in adults, haemorrhagic or thrombotic events may also occur in children. The underlying reasons are inborn or acquired. Inherited disorders usually present during in early infancy. In order to interpret clinical and laboratory findings in children it is necessary to keep in mind some specific paediatric features. This knowledge also forms the basic requirement to choose the appropriate therapy.
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