Related Experiment Video
Updated: Aug 24, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Effect of dosing and sampling time on serum thyroxine, free thyroxine, and thyrotropin concentrations in dogs
Timothy A Ness1, Sheila M Torres, Elizabeth A Kramek
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA.
Abstract:
Thirty-eight dogs with orthopedic disorders received etodolac, an NSAID, at 10.0 to 13.3 mg/kg PO once daily for 14 to 19 days. Mean total thyroxine (T4), free thyroxine (fT4), and canine thyrotropin (cTSH) values before and after etodolac administration were compared using paired t-tests. A significant (P <.05) decrease in T4 values occurred after etodolac administration with 21% of these values falling below the reference range. A significant (P <.05) increase in cTSH following etodolac administration, but none of the values was above the reference range. No significant changes occurred in mean fT4 values; however, 10% of the values fell below the reference range. In conclusion, T4 and fT4 test results should be interpreted with caution in dogs receiving etodolac.
Related Concept Videos
Dosage Regimen: Multiple Oral Dosage
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses
Drug Accumulation During Multiple Dosing: Repetitive IV Injections
Therapeutic Drug Monitoring: Drug Analysis Methods
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship
