Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Proteins, recognition networks and developing interfaces for macromolecular biosensing.

Mauro Sergi1, John Zurawski, Simon Cocklin

  • 1Department of Biochemistry and A. J. Drexel Institute of Basic and Applied Protein Science, Drexel University College of Medicine, 11102 New College Building, MS 497, 245 N. 15th Street, Philadelphia, PA 19102, USA.

Journal of Molecular Recognition : JMR
|May 12, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early immune events during SARS-CoV-2 infection impact memory T and B cell responses.

Communications biology·2026
Same author

HIV virion capturing liposomes for therapeutic vaccination.

Biomaterials·2026
Same author

HIV Virion Capturing Liposomes for Therapeutic Vaccination.

bioRxiv : the preprint server for biology·2025
Same author

Identification of polyreactive antibodies by high throughput enzyme-linked immunosorbent assay and surface Plasmon resonance.

Journal of immunological methods·2025
Same author

Monovalent Lectin Microvirin Utilizes Hydropathic Recognition of HIV-1 Env for Inhibition of Virus Cell Infection.

Viruses·2025
Same author

Selective and brain-penetrant ACSS2 inhibitors target breast cancer brain metastatic cells.

Frontiers in pharmacology·2024

Researchers are developing novel molecular interfaces to improve biosensor technology for detecting protein interactions. This work focuses on coiled coil and lipid bilayer interfaces for advanced biomedical and biotechnological applications.

Area of Science:

  • Biotechnology
  • Biomedical Engineering
  • Molecular Biology

Background:

  • Genomics and proteomics advancements enable comprehensive protein identification and the study of complex biological networks.
  • Biosensors are crucial for detecting biomolecular interactions, but their development has historically overemphasized sensor platforms over molecular interfaces.
  • Molecular interfaces are critical sensor components that interact with analytes to generate detectable signals.

Purpose of the Study:

  • To investigate the role of molecular interfaces in advancing biosensor technology.
  • To identify and design novel molecular interfaces for enhanced biosensor performance.
  • To expand biosensing capabilities for multiplexed target detection in biologically relevant environments.

Main Methods:

Related Experiment Videos

  • Investigated coiled coil molecular interfaces for biosensor applications.
  • Studied lipid bilayer interfaces for their potential in biosensing.
  • Focused on designing molecular interfaces to improve signal transduction and analyte interaction.

    • Main Results:

    • Demonstrated the potential of coiled coil and lipid bilayer interfaces to enhance biosensor capabilities.
    • Showcased the utility of these interfaces for multiplexed target detection.
    • Highlighted the importance of molecular interfaces in creating biologically relevant sensing environments.

    Conclusions:

    • Molecular interfaces are key to overcoming limitations in current biosensor development.
    • Coiled coil and lipid bilayer interfaces offer promising avenues for next-generation biosensing technologies.
    • This research paves the way for improved biosensor utilization in biomedical and biotechnological fields.