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Updated: Aug 10, 2026
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Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
[Cellular changes in non-small cell lung cancer after neoadjuvant therapy]
K Junker1, K-M Müller, S Abker
1Institut für Pathologie, Universitätsklinik Bergmannsheil, Bochum. klaus.junker@ruhr-uni-bochum.de
Der Pathologe
|May 13, 2004
Summary
Microscopic analysis of non-small cell lung cancer (NSCLC) after neoadjuvant therapy revealed significant cellular and nuclear enlargement. However, these morphometric changes do not correlate with treatment response, cautioning against post-therapy grading.
Area of Science:
- Oncology
- Pathology
- Morphometry
Context:
- Neoadjuvant therapy is increasingly used for non-small cell lung cancer (NSCLC).
- Microscopic examination of post-neoadjuvant NSCLC specimens shows subjective cytologic changes.
- Objective morphometric analysis is needed to quantify these changes.
Purpose:
- To objectively assess morphometric changes in NSCLC cells and nuclei after neoadjuvant therapy.
- To determine if these changes correlate with the degree of tumor regression.
- To evaluate the reliability of post-therapy grading and diagnosis.
Summary:
- Morphometric analysis of 24 NSCLC adenocarcinomas post-neoadjuvant therapy showed significant cellular and nuclear enlargement.
- Cytomorphological changes were observed in 75% of specimens compared to untreated tissue.
- No significant correlation was found between cellular/nuclear parameters and therapy-induced tumor regression.
Impact:
- Morphometric changes do not predict treatment success in NSCLC.
- Post-neoadjuvant therapy grading of NSCLC is not recommended.
- Diagnosis of large cell anaplastic carcinoma should be made with caution after neoadjuvant treatment.
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