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A Method for Generating Pulmonary Neutrophilia Using Aerosolized Lipopolysaccharide
Published on: December 15, 2014
[Effect of Cryptoporus volvatus (Peck) Schear on leukotriene production from polymorphonuclear leukocytes in rats]
Sai-hong Jin1, Qiang-min Xie, Xiao-xia Lin
1Zhejiang Respiratory Drugs Research Laboratory of State Drugs Administration of China, Medical College of Zhejiang University, Medical College of Hangzhou Normal University, Hangzhou, Zhejiang, China.
Objective:
To study action of Cryptoporus volvatus ferment substance (CVFS) on leukotriene production of polymorphonuclear leukocytes in rats.
Methods:
The level of slow reaction substance (SRS) and leukotriene B4 (LTB4) in polymorphonuclear leukocytes (PMNs) in rats in vitro were determined with bioassay and HPLC.
Results:
CVFS 0.9, 2.7 g.kg-1 by ig significantly inhibited SRS and LTB4 production in PMNs in rats in vivo.
Conclusion:
The inhibition effect of CVFS on SRS and LTB4 release may be related to its mechanism of anti-inflammation and anti-asthma.
