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[Studies on liver-toxicity in rhigoma of Dioscorea bulbifera]
Xing-qi Tan1, Jin-lan Ruan, Hai-sheng Chen
1NO. 98 Hospital of PLA, Huzhou 313000, Zhejang, China. tanxq@sohu.com
Abstract
Objective:
To explore the liver-toxic fraction in Rhigoma of Dioscorea bulbifera.
Method:
The rats were randomized into four groups: control group (20% PVP-water), T001(10% total methanol extraction), F002(5% chloroform fraction) and F003(5% methanol fraction). Direct bilirubin (DBil) and Glutamic-pyruvic transaminase (GPT) were examined, and liver index was measured. The histological and morphological observations were performed with optical and electrical microscope.
Result:
T001 and F002 showed significant liver toxicity.
Conclusion:
The chloroform fraction was the liver-toxic fraction of D. bulbifera.
