Related Experiment Video
Updated: Aug 24, 2026
In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
Published on: October 27, 2020
[Yixintong tablet's protection against experimental myocardial ischemia]
Jin-hua Piao1, Pei-zhi Tong, Hong Zhang
1Pharmacology Department, Shanxi Institute for Drug Control, Taiyuan 030001, Shanxi, China. Mary paio@263.net
Objective:
Various models of experimental myocardial ischemia were set up to ovbserve the Yixinton's protection against ischemia.
Method:
Models of experimentally acute myocardial ischemia were made by ligature or medication (pituitrin or isoprenaline) to check the indices of ECG, hemodynamics, and morphology.
Result:
A dosage of Yixintong tablets 100 mg/kg, 200 mg/kg was given to rats by gavage; the rats had undergone a thirty-minute ligatute of coronary lef anterior descending branch, and used as a model of ischemic reperfusion. The observations showed that Yixintong tablets exerted a recovery effect on heart rate, blood pressure, internal pressure of left ventricule and its peak/trough rate (+/- dp/dtmax), and ST segment (electrocardiogram). The tablet markedly reduced the myocardial infarct size of the coronary-ligatured rats. The tablet benefited the rats with pituitrin(iv)- or isoprenaline(ip)-induced acute myocardial ischemia to reverse any ST deviation and T-wave fall.
Conclusion:
Yixintong has a protective and therapeutic action to the experimental myocardial ischemia.
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