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Published on: July 30, 2020
[Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes]
Sheng-jun Mao1, Shi-xiang Hou, Hui Jin
1School of Pharmacy, Sichuan University, Chengdu 610041, Sichuan, China.
Objective:
To study the preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes.
Method:
3-succinic-30-stearyl glycyrrhetinic acid(Suc-GAOSt), one of the amphiphilic glycyrrhetinic acid derivatives, was synthesized as targeting molecules, liposomes surface-modified with glycyrrhetinic acid has been produced with ethanol injection method.
Result:
Targeting molecules can be mixed into the liposomal membrane. It was confirmed that the targeting molecules is 9% of the total lipids at the most in the liposomes.
Conclusion:
Liposomes surface-modified with glycyrrhetinic acid was successfully prepared, which is considered to be a potential approach targeting to hepatocytes.
