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Granulomatous meningitis as a late complication of iodized oil myelography

Nyoka N Ruberu1, Yuko Saito, Naoko Honma

  • 1Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Japan.

Neuropathology : Official Journal of the Japanese Society of Neuropathology
|May 14, 2004
PubMed

Insights

A late complication of iodized oil myelography, foreign-body granulomatous meningitis, caused severe cognitive impairment in an elderly patient. Autopsy revealed ossified iodized oil deposits leading to this rare neurological condition.

Area of Science:

  • Neuropathology
  • Radiology

Background:

  • Iodized oil myelography is a diagnostic imaging technique.
  • Complications can arise from retained contrast agents.

Observation:

  • An 83-year-old male with kyphoscoliosis presented with cognitive impairment.
  • Autopsy revealed granulomatous meningitis with ossified iodized oil deposits on the brain surface.

Findings:

  • Microscopic examination showed foreign-body reactions to iodized oil, forming ossified structures.
  • The pathology was consistent with foreign-body granulomatous meningitis.

Implications:

  • This case highlights a rare, late-onset complication of iodized oil myelography.
  • Retained iodized oil can lead to chronic inflammation and neurological deficits.

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