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Updated: Jun 24, 2026

Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
Published on: May 16, 2022
Calcitonin gene-related peptide: role in airway homeostasis
Azzeddine Dakhama1, Gary L Larsen, Erwin W Gelfand
1National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA. Dakhamaa@njc.org
Abstract:
The lung is an important source of sensory neuropeptides that modulate airway function in health and disease. Among these neuropeptides, calcitonin gene-related peptide (CGRP) plays a prominent role. CGRP is constitutively expressed in normal lungs where it localizes to a specialized subset of epithelial cells (neuroendocrine cells) and sensory C fibers distributed to pulmonary airways, blood vessels and lymphoid tissue. CGRP can mediate multiple effects, some of which have potential implications in airway homeostasis. These include vasoregulation, bronchoprotection, anti-inflammatory actions and tissue repair. Targeting these effects of CGRP could be a future avenue for modulation of certain aspects of airway diseases.
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