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Immunological consequences from exposure to benzo(a)pyrene during pregnancy

P Urso1, W Zhang, J R Cobb

  • 1Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, Georgia 30310-1495.

Scandinavian Journal of Immunology. Supplement
|January 1, 1992
PubMed

Progeny and maternal immune status after benzo(a)pyrene (BP) exposure of mothers at mid-pregnancy is disrupted in fetal liver (FL), in spleen and in thymus during pregnancy and postnatally. Mice suffer deficiencies in splenic and thymic mixed lymphocyte responses (MLR), and disorientations of T antigen expressing cells, punctuated by exorbitant increases in Lyt2, especially in FL. FL Lyt2 do not suppress an MLR, while Lyt1 mediate suppression. Isolated Thy1 show a weak response to Concanavalin A; FL Thy1 weakly express an MLR. Maternal macrophages and progeny B cells are also functionally abnormal. Thus, BP induces generalized immune deficiency that may affect ontogeny and which is potentially deleterious to health.

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