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Clean TOCSY transfer through residual dipolar couplings.

Frank Kramer1, Steffen J Glaser

  • 1Institut für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|May 14, 2004
PubMed
Summary

Most conventional Clean TOCSY sequences are inefficient for dipolar transfer due to phase alternation. New clean dipolar TOCSY sequences are developed for efficient transfer, overcoming limitations in residual dipolar coupling applications.

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Area of Science:

  • Magnetic Resonance Spectroscopy
  • Nuclear Magnetic Resonance (NMR)

Background:

  • Cross-relaxation compensated (Clean) Total Correlation Spectroscopy (TOCSY) sequences are widely used in NMR.
  • Applications in residual dipolar couplings (RDCs) require efficient spin transfer.

Purpose of the Study:

  • To analyze the transfer efficiency of conventional Clean TOCSY sequences for RDC applications.
  • To develop novel Clean TOCSY sequences with improved performance for dipolar transfer.

Main Methods:

  • Theoretical analysis of phase-alternating mixing sequences.
  • Derivation of a new family of clean dipolar TOCSY sequences.

Main Results:

  • Most conventional Clean TOCSY sequences exhibit very low transfer efficiency for dipolar transfer.

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  • Theoretical analysis shows suppression of cross-relaxation inherently excludes dipolar transfer in phase-alternating sequences.
  • The newly derived sequences demonstrate excellent transfer efficiencies across a wide range of offset frequencies.

    • Conclusions:

    • Conventional Clean TOCSY sequences are unsuitable for applications requiring efficient dipolar transfer.
    • The new family of clean dipolar TOCSY sequences offers a significant improvement for RDC studies and other applications benefiting from efficient dipolar transfer.