Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A collaborative study to establish a Korean Standard for factor VIII:C concentrate.

Hye Na Kang1, Soon Nam Kim, Seok Ho Lee

  • 1Biologics Evaluation Department, Korea Food and Drug Administration, 5 Nokbun-Dong, Eunpyung-Gu, Seoul, South Korea 122-704. hyena52000@yahoo.com

Thrombosis Research
|May 14, 2004
PubMed
Summary

This study evaluated a candidate for the Korean Standard for factor VIII:C concentrate. Both one-stage clotting and chromogenic assays confirmed its suitability, though potencies differed slightly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and Safety of Pelubiprofen for Primary Dysmenorrhea: A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Two-Period Crossover Trial.

Journal of clinical medicine·2026
Same author

An international survey of radiological protection in medical research programmes involving human volunteers.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2026
Same author

Can posttreatment blood inflammatory markers predict poor survival in gynecologic cancer?: a systematic review and meta-analysis.

Frontiers in immunology·2025
Same author

Chemically Anchored PbS-2PACz CQDs Inks for Scalable HTL in Narrow-Bandgap and All-Perovskite Tandem Solar Cells.

Small (Weinheim an der Bergstrasse, Germany)·2025
Same author

Rectal Leiomyosarcoma Treated With Surgery and Adjuvant Radiotherapy: A Case Report With a Brief Review of Radiotherapy Techniques From a Radiation Oncologist's Perspective.

Cureus·2025
Same author

Erratum to: Corrigendum: 2023 Korean Society of Menopause - Osteoporosis Guidelines Part I.

Journal of menopausal medicine·2025

Area of Science:

  • Biochemistry
  • Hematology
  • Clinical Chemistry

Background:

  • Factor VIII:C concentrate is crucial for treating hemophilia A.
  • Establishing reliable national standards is essential for accurate potency measurements.
  • Previous standards may require updates to ensure consistency and accuracy.

Purpose of the Study:

  • To evaluate a candidate material for its suitability as a Korean National Standard for factor VIII:C concentrate.
  • To compare the performance of one-stage clotting and chromogenic assays in determining factor VIII:C potency.
  • To ensure accurate and reliable quantification of factor VIII:C concentrate in Korea.

Main Methods:

  • A collaborative study involving five laboratories (three manufacturers, two national control labs).

Related Experiment Videos

  • Potency determination using both one-stage clotting assay and chromogenic assay.
  • Adherence to International Society on Thrombosis and Haemostasis recommendations for precision and accuracy.

    • Main Results:

    • Data showed good agreement in calibration against the International Standard across laboratories and assays.
    • A notable difference in overall potency was observed between the two assay methods.
    • Chromogenic assay yielded a potency approximately 17% lower than the one-stage clotting assay (6.7 IU/vial vs. 8.4 IU/vial).

    Conclusions:

    • The candidate material is suitable for adoption as a Korean National Standard for factor VIII:C concentrate.
    • The study highlights the importance of assay method selection in potency determination.
    • Standardization efforts are vital for consistent hemophilia A treatment globally.