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Single footshock attenuates c-Fos expression induced by 5-HT2A receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine
Takeshi Izumi1, Yuji Kitaichi, Shin Nakagawa
1Department of Psychiatry, Hokkaido University Graduate School of Medicine, Neural Function, North 15, West 7, Sapporo 060-8638, Sapporo, Japan. tizumi@med.hokudai.ac.jp
Abstract:
Administration of 3 mg/kg 5-hydroxytryptamine2A/2C (5-HT2A/2C) receptor agonist (+/-)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) induced c-Fos expression in all areas of the rat neocortex. The single footshock 24 h before DOI administration significantly attenuated DOI-induced c-Fos expression in layer IV of the primary somatosensory cortex. These changes in c-Fos expression suggest an adaptational change in the somatosensory cortex by acute stress.
