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Related Experiment Videos

Hypothalamic-pituitary-adrenal axis function in ankylosing spondylitis.

R Imrich1, J Rovensky, M Zlnay

  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 833 06 Bratislava, Slovakia. richard.imrich@savba.sk

Annals of the Rheumatic Diseases
|May 14, 2004
PubMed
Summary

Ankylosing spondylitis patients show normal hypothalamic-pituitary-adrenal (HPA) axis function and responsiveness. Inflammatory markers like IL-6 and TNFalpha were elevated, but HPA axis function remained intact during dynamic testing.

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Area of Science:

  • Endocrinology
  • Immunology
  • Rheumatology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
  • The hypothalamic-pituitary-adrenal (HPA) axis plays a crucial role in stress response and immune regulation.
  • Potential HPA axis dysfunction in AS requires investigation.

Purpose of the Study:

  • To evaluate the basal function of the HPA axis in AS patients.
  • To assess the responsiveness of the HPA axis to dynamic testing in AS patients.
  • To explore the relationship between HPA axis function and inflammatory markers in AS.

Main Methods:

  • Insulin-induced hypoglycemia (IIH) test was performed on 17 AS patients and 11 healthy controls.
  • Plasma levels of glucose, cortisol, ACTH, and inflammatory cytokines (IL-6, TNFalpha) were measured.

Related Experiment Videos

  • HPA axis response was assessed by measuring ACTH and cortisol levels post-IIH.

    • Main Results:

    • Basal cortisol levels showed a trend towards being lower in AS patients.
    • Concentrations of IL-6 and TNFalpha were significantly higher in AS patients compared to controls.
    • Despite elevated inflammation, the HPA axis demonstrated preserved responsiveness to IIH, with comparable ACTH and cortisol responses to controls.
    • A different course of glycemia was observed in AS patients during the IIH test.

    Conclusions:

    • The HPA axis function and responsiveness are not impaired in patients with ankylosing spondylitis.
    • Elevated IL-6 and TNFalpha in AS do not appear to compromise HPA axis integrity.
    • The altered glycemic response during IIH in AS warrants further investigation.