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Updated: Aug 24, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
CD40-associated TRAF 6 signaling is required for disease induction in a retrovirus-induced murine immunodeficiency
Kathy A Green1, Cory L Ahonen, W James Cook
1Department of Microbiology and Immunology, 1 Medical Center Dr., Dartmouth Medical School, Lebanon, NH 03750, USA. Kathy.A.Green@dartmouth.edu
Abstract:
LP-BM5 retrovirus-infected C57BL/6 mice develop splenomegaly, lymphadenopathy, hypergammaglobulinemia, and immunodeficiency; thus, this disease has been named mouse AIDS. In this syndrome, CD154/CD40 interactions are required for but do not mediate disease by upregulation of CD80 or CD86. We report here that there is nonetheless a necessity for CD40 signaling competence, specifically an intact tumor necrosis factor receptor-associated factor 6 (TRAF 6) binding site.
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