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[Resistance to antivitamins K]
J M Sánchez Villegas1, J Piqueras, I Nicolau
1Servicio de Hematología y Hemoterapia, Ciudad Sanitaria Valle de Hebrón, Barcelona.
Sangre
|August 1, 1992
Abstract:
Resistance to oral anticoagulant is a rare phenomenon. We report the case of a 32-year-old woman who required anticoagulation due to a deep venous thrombosis. She gradually developed resistance to acenocumarol and warfarin. Although the HPLC (high performance liquid chromatography) method proved satisfactory acenocumarol levels in plasma, therapeutic anticoagulation was not achieved. The mechanisms of resistance are discussed.