Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transplantation for stroke.

Ben Roitberg1

  • 1Department of Neurosurgery, University of Illinois at Chicago, Chicago, IL, USA. roitberg@uic.edu

Neurological Research
|May 15, 2004
PubMed
Summary

Neural repair research explores cell replacement and support strategies to mitigate stroke damage. Combination therapies hold promise for restoring lost brain structure and function after stroke.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocrine assessment, chemotherapy, nonsurgical treatment, and rehabilitation for osteoporotic spine fractures: WFNS spine committee recommendations.

Journal of neurosurgical sciences·2022
Same author

Mobility-Preserving Surgery for Lumbar Spinal Stenosis: WFNS Spine Committee Recommendations.

World neurosurgery: X·2020
Same author

Posterior Surgical Techniques for Cervical Spondylotic Myelopathy: WFNS Spine Committee Recommendations.

Neurospine·2019
Same author

Implantation and testing of WFMA stimulators in macaque.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2017
Same author

In reply: simulating ventriculostomy.

Neurosurgery·2014
Same author

Sensory and motor skill testing in neurosurgery applicants: a pilot study using a virtual reality haptic neurosurgical simulator.

Neurosurgery·2013

Area of Science:

  • Neuroscience and Regenerative Medicine
  • Central Nervous System (CNS) repair and neuroplasticity

Background:

  • Stroke is a leading cause of disability and mortality globally, necessitating research into neural repair.
  • Current research focuses on partial solutions for brain repair, including neuronal replacement and support.

Purpose of the Study:

  • To review current strategies and challenges in neural transplantation for stroke recovery.
  • To explore various cell types and therapeutic approaches for restoring brain function post-stroke.

Main Methods:

  • Review of preclinical studies in rodent and non-human primate models of stroke.
  • Analysis of different cell transplantation strategies: cell types, delivery methods, and timing.
  • Evaluation of combination therapies for enhanced neural repair and functional recovery.

Main Results:

  • Early transplantation studies in rats showed graft survival but limited efficacy.
  • Diverse cell sources (fetal, stem, clonal lines) have been investigated with varying success and challenges.
  • Combination therapies integrating cell replacement, trophic support, and plasticity enhancement are considered the future direction.

Conclusions:

  • Restorative treatment for stroke is an evolving field with numerous proposed and tested strategies.
  • Future advances require improved animal models and a move towards combination therapies for comprehensive brain repair.
  • Combination therapy is likely essential to replace lost neurons, support existing ones, and promote functional recovery after stroke.

Related Experiment Videos