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Updated: Aug 24, 2026

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
Published on: April 11, 2019
Pathogenic roles of B cells in human autoimmunity; insights from the clinic
Flavius Martin1, Andrew C Chan
1Department of Immunology, One DNA Way, MS-34, South San Francisco, CA 94080 USA. flavius@gene.com
Abstract:
The pathogenic roles of B cells in human autoimmune diseases involve a multitude of mechanistic pathways and include the well-established contributions of autoantibodies and immune complexes that induce local inflammatory reactions and tissue destruction. Recent results using several novel B cell-directed therapies have provided new insights into additional roles of B cells in human autoimmunity. In this review, we will highlight some of these studies and discuss how clinical insights parallel murine models of normal immunity and autoimmunity.
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