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Design and synthesis of chromogenic thiopeptolide substrates as MetAPs active site probes

Yong-Mei Cui1, Jing-Ya Li, Ling-Ling Chen

  • 1Chinese National Center for Drug Screening, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 189 Guo Shou Jing Road, ZhangJiang Hi-Tech Park, Shanghai 201203, China.

Bioorganic & Medicinal Chemistry
|May 15, 2004
PubMed

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Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...