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Circulating free nitrotyrosine in obstructive sleep apnea.

Anna Svatikova¹, Robert Wolk, Hui H Wang

¹Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology

|May 15, 2004

Summary

Obstructive sleep apnea (OSA) does not increase circulating free nitrotyrosine, a marker of oxidative stress. This study suggests repetitive hypoxemia in OSA patients does not elevate nitric oxide-mediated oxidative stress.

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Area of Science:

Cardiovascular Physiology
Sleep Medicine
Biomarkers

Background:

Obstructive sleep apnea (OSA) is linked to cardiovascular disease, endothelial dysfunction, and oxidative stress due to nocturnal hypoxemia.
Circulating free nitrotyrosine is a biomarker for nitric oxide (NO)-induced oxidative/nitrosative stress.
Nitrosative stress is implicated in cardiovascular disease development.

Purpose of the Study:

To test if severe hypoxemia from OSA increases NO-mediated oxidative stress.
To investigate the relationship between OSA, hypoxemia, and circulating free nitrotyrosine levels.

Main Methods:

Studied 10 men with newly diagnosed moderate to severe OSA and 10 healthy male controls.
Measured free nitrotyrosine using liquid chromatography-tandem mass spectrometry before and after untreated apneic sleep.

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Compared nitrotyrosine levels between groups and time points.

Main Results:

Baseline nitrotyrosine levels were similar in both OSA and control groups.
Neither normal nor apneic sleep significantly altered plasma nitrotyrosine levels in either group.
OSA was not associated with increased circulating free nitrotyrosine.

Conclusions:

Repetitive hypoxemia in OSA does not appear to increase NO-mediated oxidative/nitrosative stress in healthy individuals.
Circulating free nitrotyrosine may not be a reliable biomarker for OSA-related oxidative stress in this population.